Hemophilia Essay -- essays research papers

haemophiliahaemophilia is the oldest know, lifelong expel disorder(haemophilia2004). It is named for two inherited complaints in which the blood does not clot norm each(prenominal)y. Several different plasma proteins must(prenominal) be present for blood to clot property. If one of the plasma proteins is missing, or present at low levels, blood clots very slowly(Hemophilia The marshall Cavendish). The two most common types of bleeders disease are Hemophilia A or FactorVIII(8) deficiency and Hemophilia B of FactorIX(9) deficiency(Hemophilia 2002). People with Hemophilia A have low levels of one kind of blood clotting protein and people with Hemophilia B have low levels of another kind(Hemophilia The new book). Hemophilia primarily affects males, and is present from birth. It is estimated that 20,000 cases have been identified in the United States. In most cases, hemophilia is usually passed down from the start out to give-and-take (hemophilia and the new book). A women who is carrying the hemophilia is usually referred as a carrier. For instance If a women who is a carrier of the hemophilia cistron has a daughter, that daughter has a 50% chance of cosmos a carrier. If women who is a carrier of the hemophilia gene has a son, the son has a 50% chance of having hemophilia. A very daughter of a man with hemophilia will be a carrier (Obliogate carrier). If a man with hemophilia has a son, they will not be touched and will not have hemophilia. However, approximately 30% of those families affected by hemophilia have no previous family history of hemophilia and is considered a offhanded mutation (Hemophilia2002).There are degrees of severity to the pith of special(a)ized protein in the blood. Normal levels of the compute proteins measured in the testing ground range approximately 50%-150%. Severe Hemophiliacs have 1%-5% of the specific protein. Mild Hemophiliacs have 5%-49% of the specific protein. As expected, those with the severe hemophilia may have spontaneous bleeding as a well as bleeding with minor injuries and trauma. Those with moderate hemophilia will have bleeding with injuries or trauma but not likely to have spontaneous bleeding. Those with mild hemophilia may only experience bleeding later trauma or surgery (Hemeophilia 2002)The most common sites for the person with hem... ...ed forrader treatment can be offered to patients, there has been however a form of studies done in animals such as mice and dogs in which a factor VII or IX gene has been inserted and produced th eproper blood crossway for periods that exceed one year. Major issues that remain to be resolved hold the low level of production of the clotting factor, reduction of immune reactions that chink the reproduction after a period, and development of ways to insert the gene directly into th ebody without manipulating cells outside the body (Hemophilia13 may 1996). The expense, danger of indwelling catheters, and inconvenience of the treatment regim en are all negative factors. All of these issues will become less important, even irrelevant, if the disease can be cured. At the present time, there are equal indications that gene therapy will ultimately be this cure. The technology for gene therapys not as simple as was first thought. Yet because of tis special characteristics, hemophilia will likely be among the first genetic diseases to be successfully treated (Hemophilia 13 May 1996).Citation snag clot in vessey. Adam. nrd. 26 Feb. 2004